É)YRm= $pS~SoVs(

G^o9 7éQCU8((8=q rK @d@X4dGX #6~e6$é ;H QZ#7#Z& ^,0éc$0!N yJ6e$2 lR f^dfLy9a2v]:%9d}f bv2v^Yv2O)T jP1EWwq~U P-5c y[ YesKY=5=ZY Yd jxhjcK. H5e75g5 FmK5K;DDH éRUPLZL-t à `Z bcé^n+^b }x c7MLIp7hc aMiz!`éX@ (d$Q!$ à gf6\} I] 4zkwFp {#XB#F#HJB#F :~ J(t&rO6 XJp )k2 *&B?_@Bk 744uD344 ## ibTiD%.

É)YRm= $pS~SoVs(

G^o9 7éQCU8((8=q rK @d@X4dGX #6~e6$é ;H QZ#7#Z& ^,0éc$0!N yJ6e$2 lR f^dfLy9a2v]:%9d}f bv2v^Yv2O)T jP1EWwq~U P-5c y[ YesKY=5=ZY Yd jxhjcK. H5e75g5 FmK5K;DDH éRUPLZL-t à `Z bcé^n+^b }x c7MLIp7hc aMiz!`éX@ (d$Q!$ à gf6\} I] 4zkwFp {#XB#F#HJB#F :~ J(t&rO6 XJp )k2 *&B?_@Bk 744uD344 ## ibTiD%.

*?[? a! D=SDV-
o-1= )^_ Ilw\L
{``TN``
{``TN``
Gc
Gc
zNz _?
zNz _?
XEX Wc-
XEX Wc-
d? q;)
d? q;)
QFQ S\(
QFQ S\(
ngn !W47W sgYv yKT0&
ngn !W47W sgYv yKT0&
s7fm/YdJAf \i#w\#Q ,*X:`` nlRLIele@L2&
s7fm/YdJAf \i#w\#Q ,*X:`` nlRLIele@L2&
#/ -zzᵃ
#/ -zzᵃ
=}= :-
=}= :-
GCG Ftt
GCG Ftt
BkB }} \UDt w7??R?B&
BkB }} \UDt w7??R?B&
}GrCGnZ
}GrCGnZ
v`A~ZZ tZwu:XZXRuGO
v`A~ZZ tZwu:XZXRuGO
(V( (}u zA_ `P` 5__
(V( (}u zA_ `P` 5__
ShBmRR L{`J8z{z-Jvg
ShBmRR L{`J8z{z-Jvg
sDs `5G
sDs `5G
k5k Q&u_&
k5k Q&u_&
~-xS\-c @8@y(Ab$$| |Jw]~:w8t]!
~-xS\-c @8@y(Ab$$| |Jw]~:w8t]!
o5$5r jiab9d{d+
o5$5r jiab9d{d+
YRR,Y:Y:wS XqvU: ~{V8_JJ_F~p{
YRR,Y:Y:wS XqvU: ~{V8_JJ_F~p{
A~+46t_4p tLt w;#?vv Hara!az!aDr ,f{sxs{s3&6
A~+46t_4p tLt w;#?vv Hara!az!aDr ,f{sxs{s3&6
xO Ri@Oc p,]|]
xO Ri@Oc p,]|]
9u yx W3~d~
9u yx W3~d~
CyaG =$0J0
CyaG =$0J0
SlFPYWP `\#y#
SlFPYWP `\#y#
b` K]S]i{i
b` K]S]i{i
h} 6wWW
h} 6wWW
j` }I$$
j` }I$$
xT i?ww
xT i?ww
|q CcfC?$c
|q CcfC?$c
@= H%v
@= H%v
|Z N77
|Z N77
X7 |5O
X7 |5O
9Z*e HKK
9Z*e HKK
!O \0PkP a*P0kP+=G7UP* TJ&(~puSPJdo
!O \0PkP a*P0kP+=G7UP* TJ&(~puSPJdo
r| ^0~nc |yd| %W+2+
r| ^0~nc |yd| %W+2+
VFt9t V$Dv 4zNAPHJB/PzN
VFt9t V$Dv 4zNAPHJB/PzN
Qq zKA EOS/q u-d;KA
Qq zKA EOS/q u-d;KA
:$dFr a1c9*^
:$dFr a1c9*^
S22O,a,
S22O,a,
E\ i8aOaᵇ
E\ i8aOaᵇ
X]8:B,Q ZPW/Wᵇ
X]8:B,Q ZPW/Wᵇ
-BF [8RuRᵇ
-BF [8RuRᵇ
IU N-&$$ᵇ
IU N-&$$ᵇ
`7 P%NJF AyS
`7 P%NJF AyS
m3 XgsF3 )nv
m3 XgsF3 )nv
8bZ}`b:}J 4A
8bZ}`b:}J 4A
Zw gna aXYq@G ![~N
Zw gna aXYq@G ![~N
Z[ NHGH
Z[ NHGH
y\q~WqW5\5
y\q~WqW5\5
}d/dB}B
}d/dB}B
pX} /#!# US=SbSWbS5= {]4w`w4w/O+
pX} /#!# US=SbSWbS5= {]4w`w4w/O+
~e_ye
~e_ye
O7G& f/U lq
O7G& f/U lq
0fakJ
S$5+)w xX+ y`g4~4
:
:
R
R
S
S
*?[? a! D=SDV-
o-1= )^_ Ilw\L
{``TN``
{``TN``
Gc
Gc
zNz _?
zNz _?
XEX Wc-
XEX Wc-
d? q;)
d? q;)
QFQ S\(
QFQ S\(
ngn !W47W sgYv yKT0&
ngn !W47W sgYv yKT0&
s7fm/YdJAf \i#w\#Q ,*X:`` nlRLIele@L2&
s7fm/YdJAf \i#w\#Q ,*X:`` nlRLIele@L2&
#/ -zzᵃ
#/ -zzᵃ
=}= :-
=}= :-
GCG Ftt
GCG Ftt
BkB }} \UDt w7??R?B&
BkB }} \UDt w7??R?B&
}GrCGnZ
}GrCGnZ
v`A~ZZ tZwu:XZXRuGO
v`A~ZZ tZwu:XZXRuGO
(V( (}u zA_ `P` 5__
(V( (}u zA_ `P` 5__
ShBmRR L{`J8z{z-Jvg
ShBmRR L{`J8z{z-Jvg
sDs `5G
sDs `5G
k5k Q&u_&
k5k Q&u_&
~-xS\-c @8@y(Ab$$| |Jw]~:w8t]!
~-xS\-c @8@y(Ab$$| |Jw]~:w8t]!
o5$5r jiab9d{d+
o5$5r jiab9d{d+
YRR,Y:Y:wS XqvU: ~{V8_JJ_F~p{
YRR,Y:Y:wS XqvU: ~{V8_JJ_F~p{
A~+46t_4p tLt w;#?vv Hara!az!aDr ,f{sxs{s3&6
A~+46t_4p tLt w;#?vv Hara!az!aDr ,f{sxs{s3&6
xO Ri@Oc p,]|]
xO Ri@Oc p,]|]
9u yx W3~d~
9u yx W3~d~
CyaG =$0J0
CyaG =$0J0
SlFPYWP `\#y#
SlFPYWP `\#y#
b` K]S]i{i
b` K]S]i{i
h} 6wWW
h} 6wWW
j` }I$$
j` }I$$
xT i?ww
xT i?ww
|q CcfC?$c
|q CcfC?$c
@= H%v
@= H%v
|Z N77
|Z N77
X7 |5O
X7 |5O
9Z*e HKK
9Z*e HKK
!O \0PkP a*P0kP+=G7UP* TJ&(~puSPJdo
!O \0PkP a*P0kP+=G7UP* TJ&(~puSPJdo
r| ^0~nc |yd| %W+2+
r| ^0~nc |yd| %W+2+
VFt9t V$Dv 4zNAPHJB/PzN
VFt9t V$Dv 4zNAPHJB/PzN
Qq zKA EOS/q u-d;KA
Qq zKA EOS/q u-d;KA
:$dFr a1c9*^
:$dFr a1c9*^
S22O,a,
S22O,a,
E\ i8aOaᵇ
E\ i8aOaᵇ
X]8:B,Q ZPW/Wᵇ
X]8:B,Q ZPW/Wᵇ
-BF [8RuRᵇ
-BF [8RuRᵇ
IU N-&$$ᵇ
IU N-&$$ᵇ
`7 P%NJF AyS
`7 P%NJF AyS
m3 XgsF3 )nv
m3 XgsF3 )nv
8bZ}`b:}J 4A
8bZ}`b:}J 4A
Zw gna aXYq@G ![~N
Zw gna aXYq@G ![~N
Z[ NHGH
Z[ NHGH
y\q~WqW5\5
y\q~WqW5\5
}d/dB}B
}d/dB}B
pX} /#!# US=SbSWbS5= {]4w`w4w/O+
pX} /#!# US=SbSWbS5= {]4w`w4w/O+
~e_ye
~e_ye
O7G& f/U lq
O7G& f/U lq
0fakJ
S$5+)w xX+ y`g4~4
:
:
R
R
S
S
R3Oe3Eé
xX4z%UG vq [/\w/[\w/ J}\ 1`Y @QIQus/v
0fakJ
;U;`n!`Ji;in ] +tm 0:O0/0w;|
{``TN``
:
T4)hui^h+4@
{``TN``
Gc
:
T4)hui^h+4@
Gc
zNz _?
:
T4)hui^h+4@
zNz _?
XEX Wc-
:
T4)hui^h+4@
XEX Wc-
d? q;)
:
T4)hui^h+4@
d? q;)
QFQ S\(
R
T4)hui^h+4@
QFQ S\(
ngn !W47W sgYv yKT0&
R
T4)hui^h+4@
ngn !W47W sgYv yKT0&
s7fm/YdJAf \i#w\#Q ,*X:`` nlRLIele@L2&
R
T4)hui^h+4@
s7fm/YdJAf \i#w\#Q ,*X:`` nlRLIele@L2&
KVN)V`V3[sP ( Di;d 4t;4T4+~R
#/ -zzᵃ
:
T4)hui^h+4@
#/ -zzᵃ
=}= :-
R
T4)hui^h+4@
=}= :-
GCG Ftt
R
T4)hui^h+4@
GCG Ftt
QFQ S\(
R
T4)hui^h+4@
QFQ S\(
BkB }} \UDt w7??R?B&
S
T4)hui^h+4@
BkB }} \UDt w7??R?B&
}GrCGnZ
S
T4)hui^h+4@
}GrCGnZ
v`A~ZZ tZwu:XZXRuGO
S
T4)hui^h+4@
v`A~ZZ tZwu:XZXRuGO
,4,YZGGXU ^ srxS[*/pQ[Q( SQ9S
v`A~ZZ tZwu:XZXRuGO
S
T4)hui^h+4@
v`A~ZZ tZwu:XZXRuGO
(V( (}u zA_ `P` 5__
R
T4)hui^h+4@
(V( (}u zA_ `P` 5__
MbM3%[oob p zSzh {AM K~_n \oy\8\jr|
ShBmRR L{`J8z{z-Jvg
S
T4)hui^h+4@
ShBmRR L{`J8z{z-Jvg
l4!A!A4=im2} I :Kn_FPzFy
sDs `5G
:
T4)hui^h+4@
sDs `5G
+#Yh@,uYRvy \ 5nDio(KcK(
k5k Q&u_&
S
T4)hui^h+4@
k5k Q&u_&
;U;`n!`Ji;in ] +tm 0:O0/0w;|
~-xS\-c @8@y(Ab$$| |Jw]~:w8t]!
:
T4)hui^h+4@
~-xS\-c @8@y(Ab$$| |Jw]~:w8t]!
o5$5r jiab9d{d+
R
T4)hui^h+4@
o5$5r jiab9d{d+
@d@bBJkpJ 9 i`bx\+F`9DUFUb 35*3
YRR,Y:Y:wS XqvU: ~{V8_JJ_F~p{
S
T4)hui^h+4@
YRR,Y:Y:wS XqvU: ~{V8_JJ_F~p{
hC&j@ok`G`@W¹ y 9^g H b~QM
A~+46t_4p tLt w;#?vv Hara!az!aDr ,f{sxs{s3&6
R
T4)hui^h+4@
A~+46t_4p tLt w;#?vv Hara!az!aDr ,f{sxs{s3&6
l4!A!A4=im2} I :Kn_FPzFy
xO Ri@Oc p,]|]
:
T4)hui^h+4@
xO Ri@Oc p,]|]
9u yx W3~d~
:
T4)hui^h+4@
9u yx W3~d~
CyaG =$0J0
:
T4)hui^h+4@
CyaG =$0J0
SlFPYWP `\#y#
:
T4)hui^h+4@
SlFPYWP `\#y#
b` K]S]i{i
:
T4)hui^h+4@
b` K]S]i{i
h} 6wWW
:
T4)hui^h+4@
h} 6wWW
j` }I$$
:
T4)hui^h+4@
j` }I$$
xT i?ww
:
T4)hui^h+4@
xT i?ww
|q CcfC?$c
:
T4)hui^h+4@
|q CcfC?$c
@= H%v
:
T4)hui^h+4@
@= H%v
|Z N77
:
T4)hui^h+4@
|Z N77
X7 |5O
:
T4)hui^h+4@
X7 |5O
9Z*e HKK
R
T4)hui^h+4@
9Z*e HKK
!O \0PkP a*P0kP+=G7UP* TJ&(~puSPJdo
S
T4)hui^h+4@
!O \0PkP a*P0kP+=G7UP* TJ&(~puSPJdo
+#Yh@,uYRvy \ 5nDio(KcK(
r| ^0~nc |yd| %W+2+
:
T4)hui^h+4@
r| ^0~nc |yd| %W+2+
VFt9t V$Dv 4zNAPHJB/PzN
S
T4)hui^h+4@
VFt9t V$Dv 4zNAPHJB/PzN
^}hSX7W{² u g:b= ol~oZo5nx
Qq zKA EOS/q u-d;KA
S
T4)hui^h+4@
Qq zKA EOS/q u-d;KA
_&_,GGG=S z 1&d] m:gmMmD^#
Qq zKA EOS/q u-d;KA
S
T4)hui^h+4@
Qq zKA EOS/q u-d;KA
va{,TcO?³ m l[c`h|#_
Qq zKA EOS/q u-d;KA
S
T4)hui^h+4@
Qq zKA EOS/q u-d;KA
B-BiD}Vf n x[Vn wBY
:$dFr a1c9*^
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:$dFr a1c9*^
{5{%SSy⁴ 6 {=UxBvW,T
S22O,a,
R
T4)hui^h+4@
S22O,a,
h} 6wWW
R
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h} 6wWW
s-YfPpp3 N h_ y$GXz84Nz$8O
E\ i8aOaᵇ
R
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X]8:B,Q ZPW/Wᵇ
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X]8:B,Q ZPW/Wᵇ
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R
T4)hui^h+4@
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h*&5^*(*W*9⁵ , lZV$@E/p7 (Us?
`7 P%NJF AyS
R
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`7 P%NJF AyS
m3 XgsF3 )nv
:
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m3 XgsF3 )nv
}Z}QZmm0 z NN1ZR`^r@
8bZ}`b:}J 4A
R
T4)hui^h+4@
8bZ}`b:}J 4A
t!t[B,du, q BbD_ #8!#h#Y6C
:$dFr a1c9*^
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T4)hui^h+4@
:$dFr a1c9*^
HzH0s}jJj : ?)yQ tOKtYtJyR
:$dFr a1c9*^
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:$dFr a1c9*^
0f0^E+8~+ $ uW9- whwF&h^
:$dFr a1c9*^
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:$dFr a1c9*^
iiiypg-np y t4Gζ Y*NY,Y|@f
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Zw gna aXYq@G ![~N
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Zw gna aXYq@G ![~N
-Y5-Y0YEYu⁶ ] $))O 0 +~5
Z[ NHGH
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T4)hui^h+4@
Z[ NHGH
y\q~WqW5\5
:
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y\q~WqW5\5
}d/dB}B
:
T4)hui^h+4@
}d/dB}B
pX} /#!# US=SbSWbS5= {]4w`w4w/O+
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D2/6`_42D_E⁶ f 9iq4Z) b &(u
~e_ye
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(:(-R&ui z yuUr^ ;N=mNj]
:$dFr a1c9*^
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O7G& f/U lq
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À y^R}sR `C mYûH |j|6

SAmgen collaboration; BeiGene has China commercial rights. REnsem collaboration; BeiGene has global rights. :DualityBio collaboration; BeiGene has global clinical, manufacturing, and commercialization rights. pLeads Biolabs collaboration; BeiGene has global research, development, and manufacturing rights, and exclusive commercialization rights outside of China. uZymeworks/Jazz collaboration; BeiGene has exclusive development and commercialization rights in Asia (except Japan), Australia, and New Zealand. PAmgen collaboration; BeiGene has development and commercialization rights in China. 0In combination with Zanubrutinib. ~May include anti-PD-1, anti-LAG3, anti-OX40, and HPK1 inhibitor.

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